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In preclinical models, researchers are exploring effects on endothelial function, blood pressure, lipid profiles, and inflammatory biomarkers
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Emerging evidence suggests that GIPR antagonism could improve the tolerability of agonists by reducing nausea, according to a 2025 study 9
Nonetheless, these therapies possess drawbacks, notably the considerable toxicity linked to NSAIDs, which may result in gastrointestinal complications and reduced renal blood flow [12,13]
coli co-crystal structure (residues Trp 155 , Lys 179 , Ser 233 and Glu 385 )
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