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These are transcription factors in the cell nucleus that control how many mitochondria a cell builds, how efficiently those mitochondria burn fat, and how much oxidative capacity the cell has

Mov Disord (2008) 23:11306.10.1002/mds.22063 89 MeissnerWGFrasierMGasserTGoetzCGLozanoAPicciniPet alPriorities in Parkinsons disease research