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This multi-modal strategy costs less than repeated professional-only treatments producing superior long-term outcomes versus topical-only protocols potentially producing incomplete results in moderate to severe cases

Additionally, behavioral changes in the 6-OHDA mouse model were reversed by the PI3K/Akt signaling pathway (Zhang et al., 2017a), and the reduced number of dopaminergic cells and the levels of dopamine and its metabolites DOPAC and HVA were restored (Datla et al., 2007) when treated with PCs