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However, it is important to recognise that berberine is classified as a food supplement in the UK, not a licensed medicine , meaning it has not undergone the rigorous testing required by the Medicines and Healthcare products Regulatory Agency (MHRA) for pharmaceutical products
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In order for class III peroxidases to produce ROS, two conditions must be satisfied: 1) ion fluxes that lead to extracellular alkalization and 2) an abundant and recyclable oxidant as electron acceptor 37
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