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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

(PubMed) McNeill G, Avenell A, Campbell MK, et al

In some cases, these symptoms are downstream consequences of mast cell-mediated neuroinflammation

Abstract Glutathione peroxidase 1 (GPX1) is a crucial antioxidant enzyme that prevented the harmful accumulation of intra-cellular hydrogen peroxide

Switching to a gentler formulation or choosing a lower concentration of glutathione can help mitigate these issues