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12,13 Although the original approval was largely based on the potent glucose-dependent insulinotropic properties of GLP-1R activation on pancreatic -cells, it has become clear that the GLP-1R is expressed on a variety of other tissues, which produce a range of biological effects across diverse organ systems (Figure 2)

Statistical analysis performed with one-way ANOVA followed by Tukey HSD post-test

Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change: results from a randomized 2-stage dietary intervention trial

The authors' own conclusion is the important part: large-scale randomized controlled trials are still needed to establish long-term safety and to determine what, if anything, these agents do to IBD disease activity

Whether the amount found in energy drinks (or in this case, 5-Hour Energy shots, not in Monster) can produce this effect is debatable