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Several indirect mechanisms may explain why some individuals experience increased thirst while taking GLP-1 medications, even though thirst is not a direct pharmacologic effect of these agents

The horizon of weight loss therapeutics is expanding with medications like semaglutide

Is appetite suppression maintained

A recent study combining single-nucleus sequencing and spatial transcriptomics pinpointed the human hypothalamic GLP-1R-LepR co-expressing cluster, which strongly correlated with the mouse hypothalamic cluster that exhibits the second highest expression of GLP-1R in the hypothalamus [76]

Patients who maintain proper refrigeration report more predictable appetite suppression and steadier weight loss outcomes compared to those with inconsistent storage