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The mechanism of action of acarbose is complementary to that of metformin

Nrf2 mediates the DNA methylation level of RANKL promoter by regulating the activity of DNA methyltransferase 3a, participating in the regulation of ferroptosis in osteoclasts and bone homeostasis

Gastric mucosa performs limited first-pass metabolism before ethanol reaches portal circulation, reducing bioavailability slightly before systemic distribution begins

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