As noted above, the usual cysteine source comes from homocysteine, a significant product of the methylation cycle
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Y250 is located much farther from the disulfide bonds (Cys128-Cys206 in the hinge region between K1 and K2 domains, and Cys211-Cys288, Cys232-Cys271, and Cys260-Cys283 in the K2 domain) than the distances between Y198 and disulfide bonds, Cys149-Cys189 and Cys177-Cys201
Still, researchers with active malignancy are generally advised to avoid telomerase-activating compounds until more definitive safety data becomes available
It addresses the cellular foundations of the condition rather than just masking the symptoms