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A recent review of the randomised controlled trials literature concluded that while B vitamin supplementation consistently lowers homocysteine, the clinical benefit for thrombosis prevention remains uncertain (5)
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Conclusion Two thirds of an unselected group of ME/CFS patients treated for 3 months with vitamin B12 nasal drops had a favorable outcome in objective measures and subjective patient reported outcome, which were associated with a significant increase in serum vitamin B12 levels
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