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At the same time, adipose tissue functions as an active endocrine and immunometabolic organ, promoting low-grade inflammation, adipokine dysregulation, oxidative stress, and metabolic disturbance, all of which may influence the synovium, cartilage, subchondral bone, ligaments, and periarticular muscle (Shumnalieva et al., 2023
Adequate production of nitric oxide can help protect against artery-blocking clots or obstructions, heart attacks, stroke, and other cardiovascular problems
These modifications result in increased self-association, binding to albumin, and a longer half-life [20]
Common adverse events were predominantly gastrointestinal, particularly nausea, vomiting, diarrhoea, and constipation, and represented the most consistently reported adverse effects and the principal cause of treatment discontinuation