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The review covered GLP-1s roles in controlling islet function, appetite, inflammation, and cardiovascular pathophysiology, and made a critical mechanistic distinction: native GLP-1 acts primarily via paracrine and neural mechanisms (given its 12 minute plasma half-life), whereas GLP-1RA drugs with extended half-lives act systemically on GLP-1R populations inaccessible to the native peptide

7 Molecular dynamics (MD) simulations of compound 2-bound active GLP-1R

Wang S, et al

It is not only a good helper for the preparation of injectable drugs, but also a guardian ensuring the safe use of drugs

The Physiology of Glucagon-like Peptide 1