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Neurosci Biobehav Rev 175: 106218
When GLP-1 support reduces: Hunger increases Energy expenditure remains suppressed Food reward sensitivity rises So lifestyle cannot stay the same it must become more structured, not less: Higher protein, volume-based meals Resistance training + daily movement targets Sleep and stress optimisation Environmental control (food access, timing, routines) Lifestyle has to take over and that requires planning
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It directly starves the antioxidant recycling system, leading to progressively declining active GSH levels across immune cells
It metabolizes toxins, plays a vital role in sperm production and maturation, mounts an immune response to pathogens, and neutralizes free radicals implicated in skin aging, abnormal pigmentation, and diseases such as cancer, Alzheimers, and Parkinsons
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