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The core mechanism difference: dual versus triple agonism Understanding why retatrutide outperforms Mounjaro requires understanding what the glucagon receptor actually does when activated alongside GLP-1 and GIP

These agents mimic the action of endogenous GLP-1, an incretin hormone naturally secreted by intestinal L-cells in response to food intake

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So, GLP-1 agonists, or GLP-1 receptor agonists or analogs, are the medications that replicate the activity of the GLP-1 hormone

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