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By week 4-5, most people have minimal nausea

doi: 10.1016/S0140-6736(23)01478-2 89 MurakamiY.ItoM.OhsawaI

Yes, at least for knee osteoarthritis tied to excess weight

Other normal purging signs include mild dryness or flaking as dead cells shed more rapidly, temporary sensitivity that remains manageable, and brief periods of dullness before radiance emerges