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Glucagon-like peptide-1 receptor agonists (GLP-1s) are gaining traction in both primary care and specialty settings, and for good reason

The STEP clinical trials on semaglutides Ozempic and Wegovy, which has the most robust and longest term data to date, excluded people with the following mental health issues: Early studies show possible antidepressant and anti-anxiety effects of GLP1s like Ozempic

This bidirectional signaling pathway connecting the gastrointestinal tract and the central nervous system involves mechanisms associated with the intestinal peptides, in particular human incretin hormones such as anorexigenic GLP-1

Wegovy is administered as a once-weekly subcutaneous injection, with doses gradually increased over 16-20 weeks to minimise gastrointestinal side effects

When introduced at a micro dose, your body gradually builds tolerance to these receptor activations, reducing the shock of sudden appetite suppression or digestive changes