Heres how they work together: Folates role: Dietary folate converts to 5-MTHF (active folate) via the MTHFR enzyme 5-MTHF donates a methyl group to homocysteine This requires B12 as a cofactor for the enzyme methionine synthase The result: homocysteine converts to methionine B12s role: B12 (as methylcobalamin) acts as a cofactor for methionine synthase It helps transfer the methyl group from 5-MTHF to homocysteine Without adequate B12, folate gets trapped and cant donate its methyl group This is called the methyl trap What happens when one is deficient: Low B12 with adequate folate: Folate cant function properly (methyl trap) Homocysteine rises despite good folate levels Methylation slows down Can mask B12 deficiency symptoms initially Low folate with adequate B12: Not enough methyl groups available for donation Homocysteine rises Methylation impaired DNA synthesis affected Both low: Severe methylation impairment Very high homocysteine Anemia (megaloblastic) Neurological damage risk Why MTHFR mutations affect this partnership: With MTHFR mutations: Your body cant efficiently convert folate to 5-MTHF This creates a bottleneck in the methylation cycle Even with adequate B12, you dont have enough active folate to work with it Result: elevated homocysteine, poor methylation The solution: Bypass the MTHFR bottleneck by taking pre-methylated folate (5-MTHF) that doesnt require conversion
Comprehensive Health Review Our doctor carefully reviews the drugs, allergies, and past reactions to ensure that the treatment and dosage recommended are safe and suitable
Some researchers stay at a given dose longer than 4 weeks if they are still seeing results
Think about what that fatigue is costing you: Career opportunities missed because you dont have the energy to go the extra mile Precious moments with family spent feeling exhausted and irritable Health potentially declining as other body systems struggle without adequate B vitamins Quality of life diminished when youre too tired to enjoy hobbies, travel, or social activities Sometimes the cost of inaction is higher than we realize
Dosing & Protocols (Frequency, Route, and How Long They Last) Theres no standardized medical protocol for MIC injections because theyre compounded blends, not FDA-approved drugs for weight loss
