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Gibson KM, Elpeleg ON, Jakobs C, Costeff H, Kelley RI

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This physical delay is a primary mechanism for the early feelings of fullness

That semaglutide was used off-label at a lower dose approved for diabetes management implies that the observed beneficial effects in terms of weight reduction are likely underestimating the expected effect of the higher 2.4 mg dose that is currently available for weight maintenance