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Elwakiel A, Mathew A, Isermann B

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Receptor Selectivity 5-Amino 1MQ demonstrates high selectivity for NNMT, avoiding off-target effects: [3] Does NOT inhibit structurally related SAM-dependent methyltransferases: DNMT1, PRMT3, COMT Does NOT inhibit NAD+ pathway enzymes: NAMPT, SIRT1 This confirms that NAD+ and SAM increases result solely from preventing their degradation by NNMT, not from interfering with their synthesis or utilization enzymes

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The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development. (8) Ipamorelin may have exhibited a propensity to elevate growth hormone levels, potentially reaching heights of up to 80mIU/l (equivalent to an approximate concentration of 26.6ng/ml)

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