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Of the study group, 60% used tirzepatide and 40% used semaglutide

The most common effects include: Mild nausea Fullness or a heavy stomach feeling Burping Constipation Occasional loose stools You can help manage these by: Eating smaller meals Avoiding heavy or greasy foods Drinking water throughout the day Taking short walks after meals If side effects stay strong or keep you uncomfortable, a provider may adjust your dose or slow your titration schedule

Another uncommon side effect is dysphagia (trouble swallowing) or a lump-in-throat sensation

Endogenous GLP-1 is produced in the intestinal L-cells and the hindbrain (Han et al., 1997a

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