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The search strategy combined the Medical Subject Heading (MeSH) terms exenatide OR liraglutide OR semaglutide OR dulaglutide OR albiglutide OR lixizenatide AND diabetes mellitus, type 2 AND a filter to identify RCTs 14

Approximately 10% of energy-controlling gene expression, including those encoding nuclear hormone receptors and glucose and lipid metabolism enzymes, are regulated by circadian rhythm in a tissue-specific manner (Panda et al., 2002

Interestingly, despite increased expression of the anti-apoptotic protein BCL2 in failing hearts, programmed cell death still occurs, suggesting a complex regulatory process [116]

Tirzepatide's multi-pathway approach tackles inflammation at multiple levels, making it fundamentally different from traditional weight loss approaches that ignore the inflammatory component of metabolic disease

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