12 weeks: Roughly 69 mL used
Screening and identification of DNA aptamers to tyramine using in vitro selection and high-throughput sequencing
Since insulin therapy often indicates more advanced disease progression, greater severity, or additional comorbidities, which may lead to a higher risk of intestinal obstruction, and there was no statistically significant difference in intestinal obstruction risk between GLP-1RAs and other anti-diabetic medications (e.g., SGLT2 inhibitors, metformin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors), the observed reduction relative to insulin does not necessarily suggest a protective effect of GLP-1RAs against intestinal obstruction
to reconcile the genetics and observational estimates additional longitudinal and experimental studies are needed
Pawlak R, Lester SE, Babatunde T