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In addition, cancer cells chronically exposed to an acidic pH reveal a downregulation of the mitochondrial ACC2 isoform, the enzyme that regulates CPT1 activity by malonyl-CoA synthesis
Hyperammonemia (a determining factor in its pathogenesis) leads to brain dysfunction associated with neuropsychiatric and neurologic complications
Furthermore, in an ID state, the iron transport and storage functions of M2 macrophages are altered, resulting in reduced iron availability within the tumor microenvironment, further exacerbating immunosuppression and supporting tumor progression
10.1073/pnas.97.6.2940 83 KnstlerA.BacsR.GullnerG.HafezY
J Hum Genet 55:565570
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