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The discussion should include what is known, what is uncertain, what alternatives exist, and when treatment should be stopped
However, we acknowledge that studies with conflicting or non-replicable findings are equally important and should be included in comprehensive future analyses
However, human studies are still needed to establish a concrete link between ibuprofen use and glutathione depletion
Int J Nanomed 16:249268 Ilari A et al (2012) A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition
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