Since B12 plays a role in energy metabolism, some people report feeling more alert after taking their supplement, though this effect is anecdotal and not scientifically established
While a constant exposure of quinone is not necessarily representative of an in vivo scenario, it is however, much more representative of an in vitro situation, whereby a constant source of quinone is essentially available in the extracellular media during cell culture 27
CXCL 9 and CXCL 10 as Sensitive Markers of Disease Activity in Patients With Rheumatoid Arthritis

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This helps to detach B12 from the proteins that it is originally attached to