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Wu, M., Maier, E., Benz, R., and Hancock, R.E., Biochemistry , 1999, vol

The well-documented disconnect between biomarker modulation and clinical outcomes in neurodegenerative diseases illustrated most starkly by the history of anti-amyloid therapies means that statistically significant reductions in p-tau or YKL-40 do not constitute evidence of meaningful clinical benefit

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