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In some cases, intramuscular injection may be recommended by a provider

Side effect profiles differ: tirzepatide commonly causes nausea, vomiting, and appetite changes (the intended pharmacologic action), while sermorelin may produce injection-site reactions, flushing, or mild water retention from increased growth hormone

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NICE recommends choosing treatment according to the likely cause, clinical severity, risk of deterioration, absorption, adherence and the persons circumstances

Current research demonstrates their individual influences on visceral fat reduction, muscle preservation, gastrointestinal function, and bone metabolism