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The signature included proteins implicated in biological processes related to obesity and T2D (for example, adipogenesis, fatty acid metabolism, glycolysis and signaling pathways), consistent with the protein set analysis described above (Extended Data Fig

Whilst GLP-1 RA usage is effective at driving weight loss, the magnitude varies depending on factors such as the type of GLP-1 RA used, treatment duration, and the individual

This is because not everything can be measured on a semen analysis, and sperm are constantly being made and developing

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The researchers compared these GLP-treated individuals against mothers who had never used the medications but also had BMIs of about 36 before pregnancy