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In Phase 2 trial data, the most commonly reported adverse effects included: Nausea (reported in a significant proportion of participants, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite (which, whilst contributing to weight loss, can occasionally be excessive) These effects were generally described as mild to moderate in severity and tended to diminish over time as the body adjusted to the medication
hyperglycemia acts directly on glomerular podocytes to increase their permeability to albumin [85, 86], and its correction should reduce urinary protein excretion
Molecular mechanisms of cellular senescence in age-related endometrial dysfunction
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