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Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver

doi: 10.1111/cns.14209 70 LiottaALorochSWallachIKleweKMarcusKBerndtN

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The active compound in milk thistle, silymarin, has been studied for its potential role in supporting healthy glutathione levels and protecting cells from oxidative stress

Emphasizing the medical necessity of these drugs for patients with diabetes can help reframe the public narrative