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Together, these changes significantly lower the analogs affinity for IGF-binding proteins the regulatory proteins that normally limit how much circulating IGF-1 reaches cellular receptors
Unlike earlier GHRP compounds such as GHRP-6 and GHRP-2, ipamorelin exhibits a distinct selectivity profile: experimental studies have demonstrated that it does not release adrenocorticotropic hormone (ACTH) or cortisol at growth hormone-stimulating concentrations
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