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Disease stage-based indication Ongoing studies aim to bring clarity on whether there is an opportune stage to provide GLP-1RAs to those at risk or living with dementia.68 Offering adjunct therapies to GLP-1RA use in advanced stages of dementia, such as cholinesterase inhibitors and monoclonal antibodies, raises the possibility of synergistic effects, such as neuroinflammation and insulin signalling modulation potentiating the effects of amyloid clearance.4 [Kopp et al 2024] Treatment as either monotherapy or adjunct therapy would require future studies to determine the optimal disease stage for intervention

This neurotransmitter is associated with motivation, reward, and pleasure

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With medical supervision, patients benefit from: Regular check-ins and progress tracking Lab monitoring when needed Adjustments as the body adapts Transition planning for maintenance or discontinuation This reduces the risk of plateaus, side effects, and weight regain

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