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Mechanism of action Melanotan II acts as a non-selective agonist of the melanocortin receptors MC1, MC3, MC4, and MC5

These results are comparable to surgical interventions learn more about how Retatrutide compares to bariatric surgery in our detailed analysis

And often, those consequences do not fully show up until years later

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TRIUMPH-4 is the first pivotal trial to confirm that the weight-loss signal seen in Phase 2 scales with longer exposure and higher doses, and it adds several new secondary findings that reshape how researchers think about 9 mg and 12 mg as working doses