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Overall, consistency is key, as peptides work cumulatively over time

By acting on both systems at once, tirzepatide can deliver stronger effects on appetite, fullness, and metabolic health than GLP-1 medications alone

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Triple-Hormone-Receptor Agonist Retatrutide for Obesity Phase 2, NEJM , 2023 ClinicalTrials.gov TRIUMPH-1 (NCT05929066), TRIUMPH-2 (NCT05929079), TRIUMPH-3 (NCT05882045), TRIUMPH-4 (NCT05931367) FDA Wegovy prescribing information, 2025 FDA Zepbound (tirzepatide) prescribing information, 2024 Medical disclaimer: This article is for informational purposes only

Diabetes Care 41 , 258266 (2017)