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(2000) tested intranasal MT-2 at 0.025 mg/kg (approximately 1.75 mg for 70 kg person) in a Phase II erectile dysfunction trial with significant efficacy (PMID 11035391)
Potential areas of expansion include: Cardiovascular outcomes: A dedicated CVOT, if not already required as a post-marketing commitment, would evaluate whether orforglipron reduces MACE in patients with established cardiovascular disease or high cardiovascular risk, following the precedent set by the SELECT trial for semaglutide
BMJ Open 12(2):e053936
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