Several long-acting GLP-1 RAs have demonstrated CV protection in a dedicated CV outcome trial (CVOT) [7,8,9,10, 38] while the SURPASS-CVOT study (NCT04255433) for tirzepatide is ongoing and will provide further insights into whether these effects on blood pressure lowering, improvements in metabolic parameters and elevation in heart rate would combine to produce any meaningful impact on hard CV outcomes
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These are tiny sample sizes by medical research standards
Timing and lifestyle factors Heart rate naturally fluctuates throughout the day, and certain factors can amplify the effects of retatrutide on cardiac rate: Caffeine is an adenosine receptor antagonist that independently increases heart rate
As scary as all that can sound, the side effects tend to be mild, and your doctor might recommend modifying your daily dose to take one pill instead of two