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Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimers disease and amyotrophic lateral sclerosis

For example, prominin-2 (PROM2)-mediated exosomes can promote ferroptosis resistance by exporting ferritin-containing multivesicular bodies and facilitating iron efflux, thereby reducing the intracellular labile iron pool

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Additionally, analogs of the peptide have been shown to decrease infarct size in ischemia-reperfusion injuries and strengthen antioxidant defenses, highlighting their potential to protect brain health and support recovery from neurological damage (7)

Thiol-based regulation of redox-active glutamate-cysteine ligase from Arabidopsis thaliana