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Pregnant individuals, those with kidney or liver disease, and patients on anticoagulants should consult a provider before use

It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients

PMID: 12095637 View source Harris JM, Chess RB

Initial authorization is usually given for 6-8 months