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On the other hand, the simultaneous presence of both Arg244 and Lys240 leads to a less readily accessible active site, especially when considering the flexible nature of both residues, which leads to the shape of the active site pocket changing with the oscillation frequency of Arg244 and Lys240
Efficacy and safety of topiramate on weight loss: a meta-analysis of randomized controlled trials
A six-month check confirms the trends are holding, and a twelve-month panel gives a full picture, with extra attention to nutrition markers as weight loss continues
Neither approach is inherently better - they serve different budgets, different medical situations, and different risk tolerances - but they shouldn't be evaluated as substitutes for one another
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