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In the STEP UP trial, the higher semaglutide dose led to an average weight loss of 18.7% in participants without type 2 diabetes, compared to 16% for those treated with the standard dose and four percent with placebo

doi: 10.1002/mus.880140703

If it has been 1-5 days after you were supposed to take your next dose, go ahead and take the dose you missed and pick up with your regular dosing schedule from there

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the treatment is started at the dose of 2.5 mg and increased every four weeks