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doi: 10.3389/fendo.2025.1483199 Received 19 August 2024 Accepted 10 January 2025 Published 17 February 2025 Volume 16 - 2025 Edited by Brenda Kohn, New York University, United States Reviewed by Ekaterina Koledova, Merck, Germany Torben Laursen, Aarhus University Hospital, Denmark Updates Copyright 2025 Levshtein, Sharkia, Shimshi-Barash, Almagor, Albertsson-Wikland, Hochberg, Pillar and German
Secondly, we did not collect the parameters like BMD or RANKL/OPG, physical activities and diets, glucose parameters at follow-up which may have potential relationship to osteoporosis, which may lower the power of study
However, more long-term, controlled studies are needed to establish the safety of the proposed therapy
This D-retro-inverso configuration preserves the three-dimensional side-chain topology of the original FOXO4 sequence maintaining functional mimicry of the FOXO4 forkhead domains interaction surface with p53 while conferring exceptional proteolytic stability compared to the native L-amino acid sequence
