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As a small molecule synthesized through conventional organic chemistry, orforglipron can be produced at a fraction of the cost of peptide-based GLP-1 agonists, which require complex solid-phase peptide synthesis, extensive purification, and cold-chain distribution

This has led some researchers and clinicians to explore whether higher doses might be more appropriate for people with severe obesity

We started with GLP-1s like WEGOVY, have progressed to GLP-1 + GIPR targeting agents like ZEPBOUND, and are nearing entry of GLP-1 + GIPR + Glucagon (Lillys retatrutide)

GLP-1s typically are prescribed to you if youre seriously overweight, obese or have type 2 diabetes

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