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Patients ( n = 49) were mostly female (73%), average age 54 years old, with relapsing disease (78%) and an average starting body mass index (BMI) of 39.7 kg/m 2 (range 25.9, 58.9 kg/m 2

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The mGold channel was divided by the SiR channel in a pixel-by-pixel manner, and the mean of all pixels in the FOV, excluding the edges, was calculated