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Both substances affect overlapping physiological systems, particularly: Appetite regulation : Cannabis, particularly THC, is well known for stimulating appetite (colloquially termed "the munchies") by activating CB1 receptors in the hypothalamus and limbic system

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The findings indicated that surgical intervention and manipulation of the intestines might substantially suppress the contractile responses of these muscles to both stimuli

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Epidemiological evidence suggests that sulfonylurea use is associated with an approximately 20% increased risk of specific malignancies, although the causality of this association requires further validation due to current evidence limitations [10]