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This study was supported by The National Natural Science Foundation of China (31300978)

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To avoid these limitations, targeted activation of the endogenous cellular antioxidant machinery has emerged as an alternative therapeutic strategy for the reduction of oxidative stress (Davis and Pennypacker 2017

Our research uniquely highlights hepsin's role in counteracting APAP-induced liver damage, introducing an innovative combination therapy with NAC that enhances overall therapeutic effectiveness, marking a significant advancement in therapeutic approaches