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But the same reviews analysis found only baseline pulse significant in that subgroup, with BMI and BMI-by-dose interactions not significant predictors, so body composition is not established as the mechanism and the FDA calls the mechanism unknown

In consideration of the dual roles of GLP-1RAs in hypoglycemic effects and preventing CVD among T2DM patients, we reviewed the cardiovascular effects and molecular mechanisms of GLP-1RAs in CVOTs, animal models and cultured cells, and discuss how these findings transform pharmacotherapies for T2DM, and even expand the indication of this important category of anti-diabetic drugs to CVD patients without diabetes

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