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We suggest researchers determine if the epithelial cells of individuals with vascular dementia have reduced melanin levels in the vasculature of their brains and/or heart or in the area of a deep vein thrombosis or other cardiac event that may have occurred, increased lipids, and mitochondrial dysfunction

SURMOUNT-1 Trial (Jastreboff et al., 2022): Even at the 2.5 mg starting dose, participants achieved 16% weight loss