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Regression of cardiac hypertrophy in health and disease: Mechanisms and therapeutic potential

Weight loss is gradual and lifestyle-dependent

Key end points included: hospitalisation, heart failure (ICD-10-CM-I50), myocardial infarction (ICD-10-CM-I21), stroke and transient ischaemic attack (ICD-10-CM-I63, G45), development of diabetic microvascular complications (ICD-10-CM-E10.210.4) and all-cause mortality analysed 3 months to 5 years post drug initiation

Together, these ingredients influence two key brain regions: Hypothalamus: Regulates hunger and satiety Mesolimbic dopamine system: Controls motivation and reward associated with food consumption The combined effect reduces cravings and improves adherence to a reduced-calorie diet