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The refinement stage utilised AMBER (Assisted Model Building with Energy Refinement), a force field commonly used in molecular dynamics simulations
At the molecular signaling level, the combination produces simultaneous activation of pathways that are normally activated in sequence during natural wound healing
Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase i inhibitors via cooperative modulation of hypoxia-inducible factor-1
Vitamin B12 and folic acid deficiencies cause high homocysteine levels, which have been associated with increased atherosclerosis, stroke, arterial clots, and venous thrombosis risk
En particular, la glutatin reductasa pareciera ser una buena diana teraputica para la accin de antimalricos, ya que la glutatin reductasa del parsito Plasmodium falciparum es significativamente diferente en cuanto a estructura y plegamiento a la glutatin reductasa de los mamferos
