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The counter GSSSG treatment did not increase activation activity of 1 ng/ml HGF ( left orange-bar ), consistent with the earlier observation that GSSSG did not effectively modulate the HGF-c-met interaction (Figure 1e right column, orange bars 4 and 5 ), and hence served as a control trisulfide
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The step-wise dose increases exist to manage GI adaptation
Combining these peptides addresses wound healing from multiple angles: the structural matrix, the cellular migration to fill it, and the blood vessel development to support it
Acknowledgements This research was financially supported by e-conversion, a Cluster of Excellence funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) and the German Federal Ministry of Education and Research (Bundesministerium fr Bildung und Forschung, BMBF) under grant numbera 03XP0434A (FestBatt2-Oxide)
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